I don't think so. However, you should probably not use the Like operator anyways if case-insensitivity is important - instead, use regular expressions.
Dim re As New System.Text.RegularExpressions.Regex("^.+ough$", System.Text.RegularExpressions.RegexOptions.IgnoreCase) re.IsMatch("rough") ' True re.IsMatch("tough") ' True re.IsMatch("rOUGH") ' True re.IsMatch("ough") ' False
There's a lot to learn, but basically . is equivalent to ?, .* is equivalent to *, and \d is equivalent to #. You have to wrap it in ^ and $ for equivalency, too. Regular expressions are much more powerful and will do what you need.
You should probably add Imports System.Text.RegularExpressions if you plan to use them a lot. They can be compiled and reused for efficiency, too.