Contact: mam4041@med.cornell.edu

Data availability: https://www.nitrc.org/projects/biggaba

Publications:

• https://doi.org/10.1016/j.neuroimage.2017.07.021
• https://doi.org/10.1016/j.neuroimage.2019.02.059
• https://doi.org/10.1148/radiol.2020191037

These data were acquired as part of the Big GABA project, a large-scale multi-site study to determine differences in the measurement outcomes from GABA-edited and non-edited single-voxel MRS data across the three major MRI manufacturers: GE, Philips, and Siemens. The data here are only from one site (P3). Please visit the Big GABA data repository and refer to the publications above for more information.

Data types included are T1-weighted structural MRI images and single-voxel PRESS and GABA-edited MEGA-PRESS MRS data. The MEGA-PRESS data were acquired using standard GABA editing (TE = 68 ms) and symmetric macromolecule suppression (TE = 80 ms).

Twelve healthy adults (7 males, 5 females, mean age = 29 years).

MR data were acquired using a 3T Philips Achieva (Philips Healthcare, Eindhoven, Netherlands) system using a body coil for transmit and a 32-channel phased-array head coil for receive.

T1-weighted structural MRI acquisition parameters:

• Voxel resolution = 1 × 1 × 1 mm³
• TE/TI/TR (ms) = 3.1/865/6.9
• Scan duration = 7 min 10 s
• Flip angle = 8°
• Slices = 204
• FOV = 256 × 256 mm²
• Matrix size = 256 × 256 × 204
• SENSE acceleration factor = 2

General MRS acquisition parameters:

• Volume of interest = medial parietal lobe
• Voxel resolution = 30 × 30 × 30 mm³
• Spectral width = 2000 Hz
• Number of points = 2048

• TE/TR = 35/2000 ms
• Number of transients = 64

• TE/TR = 68 (for standard GABA editing) or 80 (for symmetric macromolecule suppression)/2000 ms
• Number of transients = 320