My intention is to represent the molecular docking in a very schematic way. What you see here is the protein, and the cavity represents its active site. To represent the ligand molecule I would need to draw, in a separate image, the complementary part of the circle. Maybe, also a method to obtain the same image without having to rotate it. Any ideas?
\documentclass{standalone} \usepackage{tikz} \begin{document} \begin{tikzpicture} \filldraw[fill opacity=0.5,fill=blue,rotate=23] (0,0) -- (4,0) arc (0:315:4.0cm) -- cycle; \end{tikzpicture} \end{document} 

\begin{tikzpicture} \filldraw[fill opacity=0.5,fill=orange,rotate=-23] (0,0) -- (4,0) arc (0:360-315:4.0cm) -- cycle; \end{tikzpicture}?