#[05AB1E](https://github.com/Adriandmen/05AB1E/wiki/Commands), score: 282 (251 [bytes](https://github.com/Adriandmen/05AB1E/wiki/Codepage))

 0>>>0>>>>>>>>>0>0>>>0>>>>>>>>0>>>>>0>>>0 0>>>>>>0>>>>>>>>0>>>>>>>>0>>>>0>>>>>>>0>>0 0>>>>>>>0>>>0 0>>>>>0>>>>>>>>>0>>0>>>0>0>>>>>>0 0>>>>>>>J 0>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>B

[Try it online.](https://tio.run/##yy9OTMpM/f/fwM7ODoQhwMAOhW8AJw0UDJCFMBgGCA5cKYpGZDuglsBMhKv3UkCooj1w@v8fAA)

Five characters used: [`0> JB`](https://tio.run/##yy9OTMpM/f//8Ezbw@3@Ov//G9jZ2YEwBBjYofAN4KSBggGyEAbDAMGBK0XRiGwH1BKYiXD1XgoIVbQHTgA)

**Explanation:**

1. First we construct the number `39138530688472073059231607`. We do this per digit, by pushing a `0` and increasing it by 1 per `>`, after which the entire stack of digits is joined together with `J`.
2. Then it pushes another `0` with 107 `>`s to get the number `107`.
3. After which it will convert `39138530688472073059231607` to base-107 with `B`, which is `"Hello, World!"`.