In general, interrupts are disabled when the processor enters an interrupt handler, and automatically re-enabled when the interrupt handler returns. (See CLI, SEI, and RETI instructions in the manual for more info).
When the external interrupt is fired, the interrupt flag INTF0 in the EIFR is set to 1. When interrupts are enabled and this bit is 1, the processor enters the interrupt handler. Inside the interrupt handler, this bit could again be set to 1, but the interrupt won't re-occur until after interrupts get re-enabled. You can also explicitly clear this bit to 0 by writing a 1 to the register. If you were inside the interrupt handler, an external event sets the bit, and you clear the bit before returning from the interrupt handler, than the interrupt will not be triggered again.
However, note that you can't actually set or clear INTF0 if you're using level-triggered interrupts -- it just matches the state of the pin at all times. If the pin is low, and interrupts are enabled, it will trigger the interrupt again. The only way to stop that is to disable interrupts (either globally, or by masking off the particular INT0 bit in EIMSK).