I’m designing a Class AB amplifier that needs to deliver up to 10 A RMS at frequencies as high as 100 kHz. The output stage uses Darlington transistors (TIP142 for NPN and TIP147 for PNP), powered from ±15 V rails, with an op amp driving the transistor bases. The load includes a 2 µH inductor and a 1 Ω resistor.
The datasheets for the TIP142 & TIP147 darlington devices rarely specify frequency performance. The only OEM datasheet that I have seen that shows a plot of gain vs frequency is from Onsemi, and it suggests that at 1MHz gain has fallen to less than 50 (refer image below).

That might seem OK, until you realise that DC (0Hz) gain is over 4,000 for the NPN, and over 5,000 for the PNP device (@25C, refer image below). This means that gain falls-off very rapidly as frequency increases. You may be better off choosing different devices for the output stage.

The other problem with the circuit as it now stands is that the output stage is not correctly biased for class AB, it is biased as purely class B (one could even argue it is class C), which will further reduce the ability of this circuit to provide a good output at a frequency of 100kHz. You need to add a bias network, something like this:

simulate this circuit – Schematic created using CircuitLab
The string of diodes D1 to D4 provide a voltage that keeps both output darlingtons partially turned on when output voltage is 0V. There are better ways to do this, for example a "VBE-multiplier" that thermally tracks the output transistors to keep bias currents constant as temperature changes.
Note that the feedback network shown the schematic (R4, R5, R6, C1, C2) is a suggestion only, it has not been designed to suit your application. Also note that all other components are nominal only, not to be taken as final selections - for example, the output devices are not to be construed as shown, the schematic editor did not have a the TIP14x series devices in the library.
There are other answers on this site that may help you, I will add these to this answer at a later time.
Responding to your specific questions:
Does this approach (multiplying instantaneous voltage by instantaneous current and integrating/summing over the conduction period) make sense for a Class AB stage at these current/frequency levels?
Yes, provided you are multiplying instantaneous values, and not some convenient way of expressing time-varying values with a single number, eg: RMS or average. Use a simulator for this task.
What are the best practices (analytical or SPICE-based) for accurately gauging how much heat each transistor will have to dissipate over a cycle?
Use spice. LTspice is free (seems you already have it).
Are there particular considerations for Darlingtons (e.g., higher saturation voltage, extra diode drop, etc.) that might significantly affect the power dissipation calculation?
The calculation of the power dissipation will be accurate, that is, will not be affected by any of the parameters you mentioned, provided that:
(a) you use a good simulator (eg: LTspice)
and
(b) have a good model for the Darlingtons.
You will find that the power dissipation in the output stage will be almost independent of the type of output devices used (Darlingtons, discrete BJTs, or MOSFETs). That is by the very nature of linear amplifier circuits.
UPDATE 17-Mar-2025
Your specifications seem to indicate an output power of about 100W (10A into 1Ω). A normal audio amplifier may not suit, as these are designed to deliver rated power into loads of 8Ω or 4Ω. 10A into 8Ω is 800W ! However, in general the designs are similar, but you may have to increase the number of output devices to get the higher current you need.
Also, your load is very inductive - at 100kHz, the 2uH inductor has an impedance of 1.26Ω which is larger than the 1Ω resistor. This will have consequences for the power dissipation in the output stage - power dissipation will be much higher than for a purely resistive load, which you will have to take into consideration. The simulations will reveal all this to you.
Here are some links to help you find a good amplifier design.
Introduction to audio amplifier design, with a decent 20W design in the answers:
Designing a 20W audio power amplifier
60-100W Audio Amplifier:
https://sound-au.com/project3a.htm
300-500W Audio Ampilfier:
https://sound-au.com/project68.htm
1500W Audio Ampilfier:
https://sound-au.com/project117.htm
Consider using class-G or class H to reduce power dissipation:
https://sound-au.com/articles/class-g.htm