Can function calls in other contracts change states?

In Solidity, is it possible to change states via function calls in other contracts?

For example, let's consider the code below, where we have three assumptions:

1. The function test2 is defined in the contract C2.
2. The contract object c2 of the type C2 is created at somewhere within C1.
3. We deployed C1 as a root contract.

Then, is it possible for the function call statement c2.test2() to change the values of variables in C1 (e.g., x1, x2, x3, etc)?

Contract C1 { uint x1; uint x2; uint x3; ... function test1 () public{ /* can c2.test2() change the values of variables */ /* within C1? (e.g., x1,x2,x3, etc) */ c2.test2 (); } }