If you'll check out this answerthis answer, you'll get an idea how to prove that $\Bbb Z[i]$ is a Euclidean domain. Every Euclidean domain is a PID, and in a PID, the "prime" and "irreducible" elements are the same. Also, in a general ring $R$ with a non-$0$ ideal $I$, we have that $R/I$ is an integral domain if and only if $I$ is a prime ideal of $R$.
Since you know that $2\pm i$ are irreducible in $\Bbb Z[i]$, then in particular, $5=(2+i)(2-i)$ is not irreducible, so not prime. Thus, $\langle 5\rangle$ is not a prime ideal of $\Bbb Z[i]$, and so $\Bbb Z[i]/\langle 5\rangle$ is not an integral domain.