I've stripped all the physical-significance for clarity, but I know that u[x,t] will be everywhere positive and continuous.
here are the equations in Mathematica code:
eqs = {D[u[x, t], {x, 2}] == D[u[x, t], t], u[x, 0] == c1, (D[u[x, t], x] /. x -> 1) == 0, u[0, t] == 3 c2 - c2 Integrate[u[x, t], {x, 0, 1}]} /. {c1 -> 1, c2 -> 1} The dependent variable u represents pressure, x represents distance and t time.
The last item in eqs represents a material-balance on the gas in the system - the integral is the amount of gas distributed in the region of interest - it accounts for gas in the region of interest, stating that
gas in region-of-interest + gas in the isobaric region at the surface (not of interest) = amount of gas in the entire system at time t=0 (represented by u[x,0]==c1 and the addition of 3 C2 - I stripped numerous physical symbols out so while the equations appear flaky, it's the shape that is of interest, not the internal consistency of the simplified equations). When I try to solve this in Mathematica, regardless of whether I use Integrate or NIntegrate I get errors:
NDSolve[eqs, {x, 0, 1}, {t, 0, 1}] When using Integrate.... I get:
Equation or list of equations expected instead of .... (integral here) When using NIntegrate I get:
The integrand u[x,t] has evaluated to non-numerical values (this error message is no surprise - just including it for completeness).
I modeled this using years ago for some graduate research, and got good solutions (I built the physical system in a lab and measured transient pressure profiles etc. to validate model results, so it's a real-world problem. Now I want to see if I can solve it again with Mathematica).
The actual BC is this:

P[x,t] is the dependent variable; x & t are independent variables, everything else is a known constant.
No postings I can find here or on Wolfram.com indicate how or if MMA can do this.
I would like to know if anyone has solved a similar problem (boundary condition containing an integral of the solution itself) using MMA, and how it might be done.

u[0, t] = 3 c2 - c2 ...should beu[0, t] == 3 c2 - c2 ...andNDSolve[eqs, {x, 0, 1}, {t, 0, 1}]should beNDSolve[eqs, u, {x, 0, 1}, {t, 0, 1}], although fixing them leads to other error messages. $\endgroup$c2 -> 0instead of1allowsNDSolveto produce an answer, although this is not the problem you wish to solve. In my experience, you need to discretize your integral boundary condition to make headway. $\endgroup$