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Comparative Study
. 1983 Oct 25;258(20):12702-6.

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics

R Skinner, E Cundliffe, F J Schmidt
  • PMID: 6195156
Free article
Comparative Study

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics

R Skinner et al. J Biol Chem. .
Free article

Abstract

The enzyme which confers resistance to erythromycin in the producing organism Streptomyces erythraeus dimethylates a single adenine residue in Bacillus stearothermophilus 23 S rRNA. This corresponds to residue Ade 2058 in Escherichia coli 23 S RNA. The methylase responsible for resistance to macrolides, lincomycin, and streptogramin B-related antibiotics in Staphylococcus aureus also acts at this site.

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