Neuroscience
 2014
DOI: 10.1016/j.neuroscience.2013.10.050
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White matter astrocytes in health and disease

Iben Lundgaard
1
,
Maria Joana Osório
2
,
Benjamin T. Kress
3
et al.

Abstract: Myelination by oligodendrocytes is a highly specialized process that relies on intimate interactions between the axon and oligodendrocyte. Astrocytes also have an important part in facilitating myelination in the CNS, however, comparatively less is known about how they affect myelination. This review therefore summarizes the literature and explores lingering questions surrounding differences between white matter and grey matter astrocytes, how astrocytes support myelination, how their dysfunction in pathologic… Show more

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Cited by 267 publications

(232 citation statements)
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References 157 publications

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“…This is in accordance with previous literature data indicating low CD44, GFAP, vimentin, and nestin expression in grey matter astrocytes and high CD44, GFAP, vimentin, and nestin expression in white matter astrocytes (reviewed in Ref. 24). Increased GFAP expression has also been shown in astrocytes isolated from the corpus callosum compared with those from cortical structures (14).…”
Section: Resultssupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…This is in accordance with previous literature data indicating low CD44, GFAP, vimentin, and nestin expression in grey matter astrocytes and high CD44, GFAP, vimentin, and nestin expression in white matter astrocytes (reviewed in Ref. 24). Increased GFAP expression has also been shown in astrocytes isolated from the corpus callosum compared with those from cortical structures (14).…”
Section: Resultssupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…The establishment of this cell line from the primary astrocyte cultures is a relevant and an additional tool for the study of Ca 21 signaling in autophagy and apoptosis. It is well known that type 1 astrocytes display a fibroblast-like morphology and express the GFAP protein, the major constituent of differentiated astrocyte filaments (Eng, 1985;Lundgaard, Os orio, Kress, Sanggaard, & Nedergaard, 2014;Radany et al, 1992), which was similar to the characteristics found in the present cells.…”
Section: Discussionsupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…This is consistent with findings that show that white matter astrocytes have a higher expression level of these markers (Goursaud et al, 2009;Hassel et al, 2003;Steiner et al, 2007). These results suggest that while both mAstro subtypes express high levels of astrocyte-associated markers and present with typical astrocyte-like morphologies, CNTF-mAstro are smaller and show increased expression of astrocyteassociated markers, in line with white matter astrocytes, whereas FBS-mAstro morphologically present as larger and rounder cells, in line with grey matter astrocytes (Lundgaard et al, 2014).…”
Section: Mipscs Differentiate Into Distinctive Astrocytic Subpopulationssupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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