If you are looking to dive deep and investigate all facets of the issue, including the ULS, IIS, event logs and even performance logs, you might want to look into the SharePoint Diagnostics (SPDiag) tool that is part of SharePoint Administration Toolkit, a free tool from Microsoft.
http://technet.microsoft.com/en-us/library/dd745013(office.12).aspx
This compiles all of the logs from all servers across the farm lets you get a bird's eye view of what was going on at the given time.
It does take a few steps to set up but really can help troubleshoot an issue.
Documentation can be found on TechNet.