MouseDown is disabled too. That's because mouse events are sent to the DOM. You can subscribe to DOM events with the HtmlElement.AttachEventHandler() method. For example:
public partial class Form1 : Form { public Form1() { InitializeComponent(); webBrowser1.Url = new Uri("http://stackoverflow.com"); webBrowser1.DocumentCompleted += webBrowser1_DocumentCompleted; } void webBrowser1_DocumentCompleted(object sender, WebBrowserDocumentCompletedEventArgs e) { webBrowser1.Document.Body.AttachEventHandler("ondblclick", Document_DoubleClick); } void Document_DoubleClick(object sender, EventArgs e) { MessageBox.Show("double click!"); } }