Questions tagged [adjustment]
This tag is ambiguous and should be avoided.
150 questions
3 votes
2 answers
218 views
Should we "adjust" for age or sex when analyzing tissue gene expression to associate it with tissue function?
I am associating muscle strength (continuous variable) with muscle gene expression using linear modeling in limma R package to examine RNA sequencing-based muscle transcriptome data of about 20,000 ...
1 vote
1 answer
89 views
Is it necessary to adjust the p-value for multiple dependent variable hypotheses-tests even when I'm using Tukey?
So, supposing I'm carrying out a field experiment (agricultural data), and I'm interested to understand how four plant genotypes affect three dependent variables (yield, height, and number of leaves). ...
3 votes
1 answer
94 views
Ranks for an Asymmetric Independent Variable
I am analyzing data with a regression model where the independent variable of interest is a treatment, and I want to estimate its effect. I aim to adjust this estimate for a set of covariates, ...
0 votes
0 answers
38 views
Adjustment in DLNM - case control setting
I have data in a case-control format with a 5-year lag of exposure. I want to adjust, in addition to the strata, for the number of monitoring stations used to calculate the exposure. The problem is ...
1 vote
2 answers
111 views
How to handle factors related to the exposure but not the outcome
For example, the postprandial time significantly influences blood glucose levels, with higher levels observed when the postprandial time is short. Elevated blood glucose is a risk factor for stroke, ...
1 vote
1 answer
171 views
Why is CIHI recommending that we multiply the multiplicative error estimate by the per-capita rate?
I feel like this question is mostly about how to translate vague documentation into math than a statistics question per se, but please bear with me. I am reading the Canadian Institute for Health ...
0 votes
1 answer
592 views
whether to adjust or not adjust for baseline in longitudinal RCT
I have a longitudinal RCT data, aiming to compare the superiority of one group with high exercising to the other group with low exercising to see the improving of pain (pain is outcome). Data is ...
2 votes
1 answer
146 views
Should we adjust for this variable?
Four variables $X$, $Y$, $A$, and $B$ are assumed to have relationships as in the following diagram: Here, $X$ is the predictor and $Y$ is the outcome variable. Suppose that the research interest is ...
0 votes
1 answer
157 views
calculation of cox-adjusted survival curves
In order to leverage a cox model for calculating adjusted survival curve - one must estimate the baseline hazard function. To my understanding this has to be estimated (non parametrically) for ...
0 votes
1 answer
49 views
how to perform the pvalue correction in this analysis
How should I do the p-value adjustment for several post hoc comparisions. Should I adjust them all at once. Or should I adjutment per comparsion. Suppose ...
3 votes
1 answer
127 views
Post hoc adjustment in clinical trial
I would like to make an adjustment on a baseline variable (which has a small imbalance).This is a post hoc adjustment (I recognize, however, the limits of this adjustment which has not been pre-...
5 votes
1 answer
370 views
Is it a confounder on not?
I have a following picture and the assumption that I can estimate the effect of Treatment on Growth by accounting for dT. However, I'm not sure if Unobserved confounder is actually a confounder - it ...
0 votes
1 answer
92 views
Linear Regression using aggregate variable create multicollinearity or adjustment issue?
my group project has a number of independent binary variables x1,x2,...,xm and a dependent binary variable y. My dataset contains some million of rows. Since there are so many independent variables, ...
2 votes
2 answers
770 views
Adjusting for confounding in linear regression model
I am wondering how would the slope and intercept change after adjusting for a confounder factor. After adjustment, would the slope be lower, or higher, and the value for the intercept? Is there any ...
1 vote
1 answer
1k views
Calculate covariate-adjusted means and 95%CIs for treatment and control group separately for simple 2-arm trial
I have data for a simple 2-arm RCT, that looks as follows: ...