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\documentclass{article} \usepackage{geometry} \usepackage[skip=0.33\baselineskip]{caption} \usepackage{xcolor} \usepackage{tabularray} \UseTblrLibrary{booktabs} \newcommand\bfc[1]{\textbf{\textcolor{red}{#1}}} \usepackage{lipsum} \begin{document} \begin{table} \caption{Table} \label{tab:?} \begin{tblr}{colspec={@{} X[0.43,l] X[0.67, l] X[j] X[j] @{}}, row{1}={font=\bfseries,c,m} } \toprule Region & Inferred by experiment & Protein 1 & Protein 2 \\ \midrule \SetCell[r=4]{l} Protein interface & \SetCell[r=4]{l} V80, G83, Q88, N92, W93, W95, I98, F100, G101, A102, D111, V118 & \SetCell[c=2]{c, font=\bfseries} Structure at T0 & \\ \midrule & & F74, T75, E76, D77, M79, \bfc{V80}, P81, \bfc{G83}, L84, T86, G87, Q88, A90, L91 & V6, P7, G10, L11, L13, V14, L17, G18, F20, M21, Y24 V26, R27, M79, \bfc{V80}, L82, \bfc{G83}, L84, Y85, T86, G87, A90 \\ \midrule[dashed] & & \SetCell[c=2]{c, font=\bfseries} Equilibrated & \\ \midrule & & M1, P2, S4, W5, P7, A8, G10, L11, T12,L13, V14, P15, L17, G18, M21, G22, F25,V26, E29, Y34, 37, K39, P40, R46, V67,W68, E70, L71, D77, A78, M79, \bfc{V80}, P81,L82, \bfc{G83}, Y85, T86, G87, & S4, V6, P7, V9, G10, L11, T12, L13, V14, P15, L17, G18, F20, M21, G22, Y24, F25, V26, R27, G28, E29, G30, L31, R32 \\ \bottomrule \end{tblr} \end{table} \end{document} 

enter image description here

\documentclass{article} \usepackage{geometry} \usepackage[skip=0.33\baselineskip]{caption} \usepackage{xcolor} \usepackage{tabularray} \UseTblrLibrary{booktabs} \newcommand\bfc[1]{\textbf{\textcolor{red}{#1}}} \begin{document} \begin{table} \caption{Table} \label{tab:?} \begin{tblr}{colspec={@{} X[0.4,l] X[0.6, l] X[j] X[j] @{}}, row{1}={font=\bfseries,c,m} } \toprule Region & Inferred by experiment & Protein 1 & Protein 2 \\ \midrule \SetCell[r=4]{l} Protein interface & \SetCell[r=4]{l} V80, G83, Q88, N92, W93, W95, I98, F100, G101, A102, D111, V118 & \SetCell[c=2]{c, font=\bfseries} Structure at T0 & \\ \midrule & & F74, T75, E76, D77, M79, \bfc{V80}, P81, \bfc{G83}, L84, T86, G87, Q88, A90, L91 & V6, P7, G10, L11, L13, V14, L17, G18, F20, M21, Y24 V26, R27, M79, \bfc{V80}, L82, \bfc{G83}, L84, Y85, T86, G87, A90 \\ \midrule[dashed] & & \SetCell[c=2]{c, font=\bfseries} Equilibrated & \\ \midrule & & M1, P2, S4, W5, P7, A8, G10, L11, T12,L13, V14, P15, L17, G18, M21, G22, F25,V26, E29, Y34, 37, K39, P40, R46, V67,W68, E70, L71, D77, A78, M79, \bfc{V80}, P81,L82, \bfc{G83}, Y85, T86, G87, & S4, V6, P7, V9, G10, L11, T12, L13, V14, P15, L17, G18, F20, M21, G22, Y24, F25, V26, R27, G28, E29, G30, L31, R32 \\ \bottomrule \end{tblr} \end{table} \end{document} 

enter image description here

\documentclass{article} \usepackage{geometry} \usepackage[skip=0.33\baselineskip]{caption} \usepackage{xcolor} \usepackage{tabularray} \UseTblrLibrary{booktabs} \newcommand\bfc[1]{\textbf{\textcolor{red}{#1}}} \usepackage{lipsum} \begin{document} \begin{table} \caption{Table} \label{tab:?} \begin{tblr}{colspec={@{} X[0.3,l] X[0.7, l] X[j] X[j] @{}}, row{1}={font=\bfseries,c,m} } \toprule Region & Inferred by experiment & Protein 1 & Protein 2 \\ \midrule \SetCell[r=4]{l} Protein interface & \SetCell[r=4]{l} V80, G83, Q88, N92, W93, W95, I98, F100, G101, A102, D111, V118 & \SetCell[c=2]{c, font=\bfseries} Structure at T0 & \\ \midrule & & F74, T75, E76, D77, M79, \bfc{V80}, P81, \bfc{G83}, L84, T86, G87, Q88, A90, L91 & V6, P7, G10, L11, L13, V14, L17, G18, F20, M21, Y24 V26, R27, M79, \bfc{V80}, L82, \bfc{G83}, L84, Y85, T86, G87, A90 \\ \midrule[dashed] & & \SetCell[c=2]{c, font=\bfseries} Equilibrated & \\ \midrule & & M1, P2, S4, W5, P7, A8, G10, L11, T12,L13, V14, P15, L17, G18, M21, G22, F25,V26, E29, Y34, 37, K39, P40, R46, V67,W68, E70, L71, D77, A78, M79, \bfc{V80}, P81,L82, \bfc{G83}, Y85, T86, G87, & S4, V6, P7, V9, G10, L11, T12, L13, V14, P15, L17, G18, F20, M21, G22, Y24, F25, V26, R27, G28, E29, G30, L31, R32 \\ \bottomrule \end{tblr} \end{table} \end{document} 
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Zarko
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  • you not provide MWE (Minimal Working Example), a small but complete document with your table. Consequently your page layout is unknown.
  • To demonstrate, how you can set table, I use article documentclass and determine page layout with geometry package.
  • you can determine table width for example with tabular*, xtabular, tabularray packages ...
  • In MWE below is used tabularray package.
  • It is not entirely clear how should table looks, so in MWE is just guessing that you may you liked showed table design.
\documentclass{article} \usepackage{geometry} \usepackage[skip=0.33\baselineskip]{caption} \usepackage{xcolor} \usepackage{tabularray} \UseTblrLibrary{booktabs} \newcommand\bfc[1]{\textbf{\textcolor{red}{#1}}} \begin{document} \begin{table} \caption{Table} \label{tab:?} \begin{tblr}{colspec={@{} X[0.4,l] X[0.6, l] X[j] X[j] @{}}, row{1}={font=\bfseries,c,m} } \toprule Region & Inferred by experiment & Protein 1 & Protein 2 \\ \midrule \SetCell[r=4]{l} Protein interface & \SetCell[r=4]{l} V80, G83, Q88, N92, W93, W95, I98, F100, G101, A102, D111, V118 & \SetCell[c=2]{c, font=\bfseries} Structure at T0 & \\ \midrule & & F74, T75, E76, D77, M79, \bfc{V80}, P81, \bfc{G83}, L84, T86, G87, Q88, A90, L91 & V6, P7, G10, L11, L13, V14, L17, G18, F20, M21, Y24 V26, R27, M79, \bfc{V80}, L82, \bfc{G83}, L84, Y85, T86, G87, A90 \\ \midrule[dashed] & & \SetCell[c=2]{c, font=\bfseries} Equilibrated & \\ \midrule & & M1, P2, S4, W5, P7, A8, G10, L11, T12,L13, V14, P15, L17, G18, M21, G22, F25,V26, E29, Y34, 37, K39, P40, R46, V67,W68, E70, L71, D77, A78, M79, \bfc{V80}, P81,L82, \bfc{G83}, Y85, T86, G87, & S4, V6, P7, V9, G10, L11, T12, L13, V14, P15, L17, G18, F20, M21, G22, Y24, F25, V26, R27, G28, E29, G30, L31, R32 \\ \bottomrule \end{tblr} \end{table} \end{document}