I will replicate @xport's answer with my new LaTeX3 package tabularray. It is much easier while the images are still exactly vertically centered using this method.
Specifically, the values m or h are passed to the valign= key which centers the content, which can be found in section 2.5 Rows and Columns in the documentation.
\documentclass{article} \usepackage[a4paper,vmargin=2cm,hmargin=1cm]{geometry} \usepackage{graphicx} \usepackage{xcolor} \usepackage{tabularray} \setlength{\parindent}{0pt} \newcommand{\dummy}{% It is practically a big lie that \LaTeX\ makes you focus on the content without bothering about the layout.% } \newcommand\xx{$\displaystyle\frac{a+b}{a-b}=0$} \newcommand\yy{$\displaystyle\int_a^bf(x)\,\textrm{d}x=\frac{a-b}{a+b}$} \newcommand\zz{\fcolorbox{cyan3}{yellow9}{\parbox{\dimexpr\linewidth-2\fboxsep-2\fboxrule\relax}{\dummy}}} \begin{document} \noindent \begin{tblr}{ colspec = {X[c,h]X[c]X[c]X[c]}, stretch = 0, rowsep = 6pt, hlines = {red5, 1pt}, vlines = {red5, 1pt}, } \includegraphics[width=0.22\textwidth]{example-image-a} & \xx & \yy & \zz \\ \includegraphics[width=0.22\textwidth]{example-image-b} & \xx & \yy & \zz \\ \end{tblr} \bigskip \begin{tblr}{ colspec = {X[c,m]X[c,m]X[c,m]X[c,m]}, cell{1}{3} = {c=2}{c}, % multicolumn cell{2}{1} = {c=2}{c}, % multicolumn cell{3}{2} = {c=2}{c}, % multicolumn cell{4}{1} = {c=4}{c}, % multicolumn rowsep = 6pt, hlines = {red5, 1pt}, vlines = {red5, 1pt}, % vlines can not pass through multicolumn cells } \yy & \yy & \yy & \\ \yy & & \yy & \yy \\ \yy & \yy & & \yy \\ \yy & & & \\ \end{tblr} \end{document}

p{...}aligns the content toward the top,m{...}aligns the content toward the center, whileb{...}aligns it toward the bottom.pspecifier is standard.