JavaScript files that are not autoptimized (because they were excluded or because they are hosted elsewhere) are typically render-blocking. By adding them in the comma-separated "async JS" field, Autoptimize will add the async flag causing the browser to load those files asynchronously (i.e. non-render blocking). This can however break your site (page), e.g. if you async "js/jquery/jquery.min.js" you will very likely get "jQuery is not defined"-errors. Use with care.