This can be done with this,
$ sed -e 's/,/;/g' -e 's/;/,/1' infile test1,test2;test3 test4,test5 test6,test7;test8;test9;test10 test11,test12;test13;test14 Explanation
s/,/;/greplaces all occurrence of,with;s/;/,/1replaces the first occurrence of;with,
If you have GNU sed, you can also usetry this simple and handy,
sed 's/,/;/2g' infile