Note: This is an extended comment.
This integral can be expressed in terms of the MeijerG special function:
16/π*MeijerG[{{1},{}},{{1,1,3/2,3/2},{}},1/(16*x)]
Plotting using this expression takes about 6 seconds, compared to 12 seconds using OPs code. To obtain this expression, I first made a change of variables, replacing y by u/z where u is a new variable, and then evaluated the resulting integral
Integrate[Exp[-x*u-(u/z)^(1/2)-z^(1/2)]/z,{u,0,∞},{z,0,∞}, Assumptions->{x>0}]
which takes about 10 seconds and gives the MeijerG result.
Having a symbolic result has advantages besides plotting, for example if OP wanted to know about $x \to \infty$ asymptotics, they could use
Series[16/π*MeijerG[{{1},{}},{{1,1,3/2,3/2},{}},1/(16*x)],{x,∞,1}] (* (-EulerGamma+Log[16]+Log[x]+2 PolyGamma[0,1/2])/x+O[1/x]^(3/2) *)