RFC 8422 is "Elliptic Curve Cryptography (ECC) Cipher Suites for Transport Layer Security (TLS) Versions 1.2 and Earlier". It defines the use of EdDSA curves (25519 and 448) in Diffie-Hellman and digital signature operations.
The IANA registries for TLS Supported Groups and TLS SignatureAlgorithm have been updated to reflect RFC 8422.
I created a simple PKI with ed25519 keys throughout (using OpenSSL 3.2), configured an MQTT server (Mosquitto 2.0.18) for mutual auth, and then used the OpenSSL s_client command to simulate a client.
I can force the TLS version using openssl s_client -tls1_2 or openssl s_client -tls1_3. Both work fine, and Wireshark confirms the TLS version is as expected.
So in theory it works, but I have also tried 2 different MQTT clients and I can't get either to work!