yasm works on Mac OSX (I got it from Homebrew), and it has a GNU as syntax parser which can be enabled with -p gas (it may be necessary to also add -r gas). It is not 100% complete, but it covers mostly everything. It can output to a variety of object formats (if cross-compiling is necessary), and in my opinion it's pretty cool. You can also use NASM syntax (which is completely supported) using -p nasm (again, -r nasm may be necessary).
Sorry about necroposting, but this is a still-relevant question and I believe that it needs an acceptable answer.
as myfile.sshould do it for you. So shouldgcc myFile.s.