Based on my answer at What are the ways to position things absolutely on the page?
REVISED to make solution with nested \stackinsets. Note: The text will be vertically centered in the white box.
\documentclass{memoir} \usepackage[utf8]{inputenc} \thispagestyle{empty} \usepackage{graphicx} \usepackage{everypage} \usepackage{xcolor} \usepackage{lipsum} \usepackage{stackengine} % THESE ARE LaTeX DEFAULTS; CAN CHANGE IF NEEDED. \def\PageTopMargin{1in} \def\PageLeftMargin{1in} \newcommand\atxy[3]{% \AddThispageHook{\smash{\hspace*{\dimexpr-\PageLeftMargin-\hoffset+#1\relax}% \raisebox{\dimexpr\PageTopMargin+\voffset-#2\relax}{#3}}}} \begin{document} \def\blocktext{% This is a test of text in my parbox. Will it wrap properly? I think it will.} \atxy{0in}{11in}{% \stackinset{r}{2.5cm}{c}{0cm}{\parbox[c]{4cm}{\blocktext}}{% \stackinset{l}{2cm}{b}{2cm}{\includegraphics[width=9cm,height=3.5cm]{example-image-a}}{% \stackinset{r}{2cm}{b}{2cm}{\textcolor{white}{\rule{5cm}{3.5cm}}}{% \textcolor{blue}{\rule{\paperwidth}{7.5cm}}% }}}% } \lipsum[1-4]\clearpage \end{document}

ORIGINAL SOLUTION (without stacks):
I draw the blue with a big \rule, and then overlay a white block for the future text, and an image, and finally a \parbox for the text.
\documentclass{memoir} \usepackage[utf8]{inputenc} \thispagestyle{empty} \usepackage{graphicx} \usepackage{everypage} \usepackage{xcolor} \usepackage{lipsum} % THESE ARE LaTeX DEFAULTS; CAN CHANGE IF NEEDED. \def\PageTopMargin{1in} \def\PageLeftMargin{1in} \newcommand\atxy[3]{% \AddThispageHook{\smash{\hspace*{\dimexpr-\PageLeftMargin-\hoffset+#1\relax}% \raisebox{\dimexpr\PageTopMargin+\voffset-#2\relax}{#3}}}} \begin{document} \atxy{0in}{11in}{\textcolor{blue}{\rule{\paperwidth}{7.5cm}}} \atxy{\dimexpr\paperwidth-7cm}{\dimexpr11in-2cm}{\textcolor{white}{% \rule{5cm}{3.5cm}}} \atxy{2cm}{\dimexpr11in-2cm}{% \includegraphics[width=9cm,height=3.5cm]{example-image-a}} \atxy{\dimexpr\paperwidth-6.5cm}{\dimexpr11in-4.8cm}{\parbox[t]{4cm}{% This is a test of text in my parbox. Will it wrap properly? I think it will.}} \lipsum[1-4]\clearpage \end{document}
