Asepsis is currently not working under Mavericks. It's, in my knowledge, the only single-purpose app existing for this job. Therefore, what is the less intrusive solution to prevent .DS_Store creation after the update to Mavericks?
3 Answers
Asepsis updates have been officially released for Mavericks compatibility - http://asepsis.binaryage.com/
I've personally tested it, working like a charm!
The free app TinkerTool 5.0, which has many functions, can be used on Mavericks to disable creating .DS_Store files on network volumes, but I do not believe this has any effect on .DS_Store files on your local Mac.

- 4The setting can also be enabled with
defaults write com.apple.desktopservices DSDontWriteNetworkStores -bool true, but it only disables creating .DS_Store files on network volumes.Lri– Lri2013-11-03 13:42:58 +00:00Commented Nov 3, 2013 at 13:42 - Actually what TinkerTool does is to provide a GUI that generates many different defaults write files. It also keeps track of the ones that it creates, and it can de-install all of them using the Reset button, which puts all customizations back to their pre-TinkerTool state. This is very useful because otherwise if you create a lot of your own defaults write files, you may not remember what they all are and how to reset things back the way they were.user9290– user92902013-11-03 22:51:48 +00:00Commented Nov 3, 2013 at 22:51
BlueHarvest does not prevent the creation of .DS_Store files, but it can delete them automatically.

You can also delete .DS_Store files by using find:
find / -name .DS_Store -delete - This is actually the closest solution to what I'm looking for. However, there is a quiet important delay between the creation of a given .DS_Store file and it detection by BlueHarvest for removal. In the situation, for example, where you're a creating an archive for a windows user, this can be annoying...cid– cid2013-11-06 20:37:46 +00:00Commented Nov 6, 2013 at 20:37