A class of languages $\mathcal{L}$ is closed against concatenation if for every pair of languages $L_1, L_2 \in \mathcal{L}$ we also have $L_1 \cdot L_2 \in \mathcal{L}$.
Here, $A \cdot B = \{ v \cdot w \mid v \in A, w \in B \}$.
A class of languages $\mathcal{L}$ is closed against homomorphism if for every language $L \in \mathcal{L}$ and every (word) homomorphism $f$ we also have that $f(L) \in \mathcal{L}$.
Here, $f : \Sigma \to \Sigma^*$ is lifted to words and sets in the natural way, i.e.
$\qquad\displaystyle f(w) = f(w_1) \dots f(w_n)$ for $w = w_1 \dots w_n$,
and
$\qquad\displaystyle f(A) = \{ f(w) \mid w \in A\}$.
(Note that can make a difference if you require $f : \Sigma \to \Sigma^+$.)
It's easy to see that the two are not the same.
Let $A = \{ w \in \{a, b\}^* \mid |w|_a \in 2\mathbb{N} \}$. Clearly, $\mathcal{A} = 2^A$ is closed against concatenation but not against homomorphism.
Let $B = \{ ww \mid w \in \{a,b\}^* \}$. Then, $\mathcal{B} = 2^B$ is closed against homomorphism but not against concatenation.
(mentioned by chi in a comment)
For completeness, $2^{\Sigma^*}$ is closed against both, and $\mathcal{A}\cdot\mathcal{B}$ against neither.