Simulation implementation and simulation results for the trial operating characteristics.

To build this site, you need to have a recent version of quarto install plus there is a dependency on the roadmap.data R package, see [https://github.com/maj-biostat/roadmap.data].

Also note, the site makes use of the development version of data.table. Use data.table::update_dev_pkg() to install.

To render an individual notebook use, for example:

quarto render notebooks/sim-design5-results.qmd --to html 

Simulations are configured via Makefile. Run make list to see all targets.

At the time of writing make sim05 has the simulations for the current design.

Rstudio: Version 2024.04.2+764 (2024.04.2+764)

cmdstanr::cmdstan_version() [1] "2.35.0"

To determine what version of quarto is being bundle with rstudio, open the terminal (inside rstudio) and type:

quarto check 

As of the time of the last commit of this document, the version used is (all paths deleted):

Quarto 1.5.52 [✓] Checking versions of quarto binary dependencies... Pandoc version 3.2.0: OK Dart Sass version 1.70.0: OK Deno version 1.41.0: OK Typst version 0.11.0: OK [✓] Checking versions of quarto dependencies......OK [✓] Checking Quarto installation......OK Version: 1.5.52 Path: - [✓] Checking tools....................OK TinyTeX: v2024.03 Chromium: (not installed) [✓] Checking LaTeX....................OK Using: TinyTex Path: - Version: 2024 [✓] Checking basic markdown render....OK [✓] Checking Python 3 installation....OK Version: 3.10.1 Path: - Jupyter: (None) Jupyter is not available in this Python installation. Install with python3 -m pip install jupyter [✓] Checking R installation...........OK Version: 4.4.1 Path: - LibPaths: - - knitr: 1.47 rmarkdown: 2.27 [✓] Checking Knitr engine render......OK 

In theory, this should pick up whatever is on your system. I think polyfill.io affected versions of quarto < 1.5 so you should probably update if you are not on the latest.