Let $R=\mathbb{C}[x,y]$. I have the following situation: $\mathbb{C} \subseteq D \subseteq R$ is affine (= finitely generated as a $\mathbb{C}$-algebra), noetherian, has field of fractions $\mathbb{C}(x,y)$, and $R$ is separable over $D$ (= $R$ is a projective $R \otimes_D R$-module).
It would be great if one can show (at least) one of the following:
(1) Without any further assumptions, $D$ is regular (= a noetherian ring such that every localization at a maximal ideal is a regular local ring).
(2) Assuming integrality of $D \subseteq R$ (but not assuming flatness) implies regularity of $D$.
(3) Assuming flatness of $D \subseteq R$ (but not assuming integrality) implies regularity of $D$.
I am most interested to show (1); however, I am afraid there is not enough information to show (1), so showing (2) would be great too. (3) may be of some interest.
Thus far I can show only a special case of (3), namely: If $D \subseteq R$ is faithfully flat, then $D$ is regular. Reason: Just apply Proposition 8 in Bourbaki's book, 10, page 59, which says the following: If $A$ and $B$ are noetherian rings with $A \to B$ faithfully flat, then regularity of $B$ implies regularity of $A$.
Sorry for not posting (yet) the specific case I have in mind; it's just that I first wish to know if the more general case is provable (maybe it can be found in a book or a paper?).