I have an issue with MMA 12.1 under Linux, specifically, xubuntu 18.04.4, and even more specifically, font rendering.
A semi-random plot, in this case,
Plot[Sin[x Cos[x]], {x, -\[Pi], \[Pi]}, ColorFunction->ColorData["SolarColors"], BaseStyle->{FontFamily->"Helvetica", 10} ] under 12.1 exported to pdf, then converted to png (using pdftocairo) looks like 
The same plot under 12.0 looks like 
Incidentally, there's no difference in quality whether I export to PDF, then convert, or whether I Export[file, graphic, "PNG"].
Observe the difference in the quality in fonts under 12.1. I'm less worried about the difference in graticules, since they should be fixable.
Same results using any of the 2D & 3D plotting functions: 12.0 results in crisp vector fonts whereas 12.1 results in dithered unreadable messes.
Searching on StackExchange has not apparently revealed a fix, but I'd certainly appreciate being pointed in the right direction.
In any case, until such a fix can be found, I'm back to 12.0.