Thread[MapAt[Thread, try, {1}], List, 1]
{{{1, a, 2}, 3, 4, {5, 6}}, {{1, b, 2}, 3, 4, {5, 6}}, {{1, c, 2}, 3, 4, {5, 6}}}
Update: Using the second and third arguments of Thread you can specify the heads and positions of arguments to thread over:
try2 = {{1, {a, b, c}, {e, f, g}}, 3, 4, {5, 6}}; Thread[MapAt[Thread, try2, {1}], List, 1]
{{{1, a, e}, 3, 4, {5, 6}}, {{1, b, f}, 3, 4, {5, 6}}, {{1, c, g}, 3, 4, {5, 6}}}
Thread[MapAt[Thread[#, List, {2}] &, try2, {1}], List, 1]
{{{1, a, {e, f, g}}, 3, 4, {5, 6}}, {{1, b, {e, f, g}}, 3, 4, {5, 6}}, {{1, c, {e, f, g}}, 3, 4, {5, 6}}}
Thread[MapAt[Thread[#, List, {3}] &, try2, {1}], List, 1]
{{{1, {a, b, c}, e}, 3, 4, {5, 6}}, {{1, {a, b, c}, f}, 3, 4, {5, 6}}, {{1, {a, b, c}, g}, 3, 4, {5, 6}}}
try3 = {{1, foo[a, b, c], bar[e, f, g]}, 3, 4, {5, 6}} ; Thread[MapAt[Thread[#, foo] &, try3, {1}], List, 1]
{foo[{1, a, bar[e, f, g]}, {1, b, bar[e, f, g]}, {1, c, bar[e, f, g]}], 3, 4, {5, 6}}
Thread[MapAt[Thread[#, bar] &, try3, {1}], List, 1]
{bar[{1, foo[a, b, c], e}, {1, foo[a, b, c], f}, {1, foo[a, b, c], g}], 3, 4, {5, 6}}
Thread[MapAt[Thread[#, foo] &, try3, {1}], foo, 1]
foo[{{1, a, bar[e, f, g]}, 3, 4, {5, 6}}, {{1, b, bar[e, f, g]}, 3, 4, {5, 6}}, {{1, c, bar[e, f, g]}, 3, 4, {5, 6}}]