NextPrime has no problems evaluating for large numbers well above $10^{14}$. I think it's safe to assume these are real prime numbers, for confirmation see the answer by @Roman (+1).
You can benchmark the performance of NextPrime and/or your analysis using AbsoluteTiming or RepeatedTiming for better statistics.
RepeatedTiming[ NextPrime[ RandomInteger[10^40] ] ,10 ] (* {0.00116824, 7254438951606515242301428266213800581027} *)
So after evaluating random large numbers repeatedly for 10 seconds, we get an average of 1.117ms per evaluation.
We expect that there will be approximately $n/Log(n)$ prime numbers smaller than $n$ (Prime number theorem), so assuming 1ms per iteration, your calculation will take more than 98 years.
With[ { n = 10^14 }, UnitConvert[ Quantity[1., "Millisecond"] * n/Log[n] ,"Years" ] ] (* Quantity[98.36705486320665, "Years"] *)
So unless your machine is much faster than mine and you have access to several hundreds of cores, even speeding things up via compilation, I think it may be hard to go over all prime numbers in the range $2$ to $10^{14}$ and do any meaningful tests on them.

Edit
After the excellent comment by @GregHurst code like the one below from here, could bring you down to a couple of weeks, without taking into account the time for your test. However, you may be limited by memory.
As pointed out by @Roman, we can know there are exactly PrimePi[10^14]$= 3204941750802$ prime numbers below $10^{14}$, and you better not try to have them all in memory (46 TB).
PrimesUpTo = Compile[{{n, _Integer}}, Block[{S = Range[2, n]}, Do[ If[S[[i]] != 0, Do[ S[[k]] = 0, {k, 2i+1, n-1, i+1} ] ], {i, Sqrt[n]} ]; Select[S, Positive] ], CompilationTarget -> "C", RuntimeOptions -> "Speed" ];
NextPrimewhich works there quite well, however. finding e.g. tenth next prime is unsatisfactorily slow (NextPrime[10^19, 10]) See these posts: What is so special about Prime? and Why does iterating Prime in reverse order require much more time?. $\endgroup$NextPrimefor such calculations, much more efficient method would involve simplyPrimePiandPrimeinstead ofNextPrime. $\endgroup$