Comment: I think you want D instead of Derivative. Also == instead of =. And you probably want the functions defined with patterns z_ etc. But there are errors that you'll have to address. (Or perhaps someone else.)
ClearAll[φ, η, r, u]; φ[z_] = q*(1/z + (-1*q)/(-1*z)); η[z_] := k*(1/z + (-1*q)/(-1*z)); r[ρ_, z_] := Sqrt[ρ^2 + z^2]; pde = D[u[t, ρ, z], {t, 2}] == D[u[t, ρ, z], {ρ, 2}] + (1/ρ)*D[u[t, ρ, z], {ρ, 1}] + D[u[t, ρ, z], {z, 2}] - ((φ[z]^4)/4)* (D[(η[z] + u[t, ρ, z] - 1)/φ[z], {ρ, 1}] D[(η[z] + u[t, ρ, z] + 1)/φ[z], {ρ, 1}] + D[(η[z] + u[t, ρ, z] - 1)/φ[z], {z, 1}] D[(η[z] + u[t, ρ, z] + 1)/φ[z], {z, 1}])* ((η[z] + u[t, ρ, z])*((η[z] + u[t, ρ, z])^2 - (φ[z]^2)/2))^(-1); bc = {u[0, ρ, z] == 0, u[t, 0, z] == 1, u[t, ρ, -6] == u[t, ρ, 6]}; NDSolve[{pde, bc}, u[t, ρ, z], {t, 0, 10}, {ρ, 0, 6}, {z, -6, 6}, Method -> {"MethodOfLines", "SpatialDiscretization" -> {"TensorProductGrid", "DifferenceOrder" -> "Pseudospectral"}}]
NDSolve::ivone: Boundary values may only be specified for one independent variable. Initial values may only be specified at one value of the other independent variable. >>
I'll leave this up for a while, but I'll probably delete it since it is not an answer. :( Unless I forget. Maybe someone else can use it.
Update
q and k have to be given numeric values for NDSolve to work. In NDSolve, ρ starts at 0 and there's a 1/ρ in the PDE, which will give you a 1/0 error (when the NDSolve finally works). There may be other such singularities to deal with, but this one was obvious.
Here NDSolve goes to work but gives the 1/0 error. The trick to get it to work is to give a complete IVP for t. The highest order derivative is two, so initial values for u and its t derivative have to be given. (I do not know if this is how you should fix your problem.)
q = 2; k = 1/10; (* random values) bc = {u[0, ρ, z] == 0, Derivative[1, 0, 0][u][0, ρ, z] == 1, u[t, 0, z] == 1, u[t, ρ, -6] == u[t, ρ, 6]}; NDSolve[{pde, bc}, u[t, ρ, z], {t, 0, 10}, {ρ, 0, 6}, {z, -6, 6}, Method -> {"MethodOfLines", "SpatialDiscretization" -> {"TensorProductGrid", "DifferenceOrder" -> "Pseudospectral"}}]
At this point, I believe I am stuck. The problem, I believe, is now a mathematical/scientific one of what the appropriate boundary and initial conditions are. It is also possible that there is an error (typo) in the PDE.
If you need to vary q and k as parameters, consider using ParametricNDSolve. But the basic NDSolve problem should be fixed first.
Sorry I can't be more help.