If we are in a position to use loose, everyday talk, then we could say we know (theory X is true and theory Y is false) if we have sufficient evidence for theory X ("more" than for theory Y) and if the two theories somehow are incompatible. Bayesian modeling is a simplified, specific, non-exclusive way to formalize and quantify what it means to have "more" evidence (enough to go with one hypothesis or theory rather than another).
One big problem is that it depends on fixing the probability of a "prior": the probability of the hypothesis (or a complete theory). This is never trivial and Bayesian theory itself provides no justification for any prior. Another big issue is that it has no good or accepted way to revise an initial prior later (after performing several updates, given incoming data). Once you selected one, you're locked in. So, it's very dubious if Bayesian modeling accurately represents the process of how we (or other sentient creatures) rationally update our beliefs (in everyday life or in science).
Given these kind of intrinsic problems, it seems best to only use Bayesian theory selection as a heuristic tool: it may help in selecting a hypothesis (or theory) that seems more promising, for the time being, but we should be prepared to overhaul the complete theory if later evidence doesn't fit (where "not fitting" may not be completely captured by the Bayesian model). Any "knowledge" it gives may only be temporary, and any underlying, deeper explanation of phenomena needs to be sought in explaining why those priors would be what we assume them to be. (For instance in physics, this would require deeper or more general causal theories.)
For an explanation of how threshold values can be calculated in a Bayesian framework, see for instance: Roberto Trotta, Bayes in the Sky: Bayesian inference and model selection in cosmology. Note the reference to Occam's razor. Bayesian modeling tries to capture part of the meaning of favoring the "simplest" theories:
Bayesian model comparison offers a formal way to evaluate whether the extra complexity of a model is required by the data, thus putting on a firmer statistical grounds the evaluation and selection process of scientific theories that scientists often carry out at a more intuitive level. For example, a Bayesian model comparison of the Ptolemaic model of epicycles versus the heliocentric model based on Newtonian gravity would favour the latter because of its simplicity and ability to explain planetary motions in a more economic fashion than the baroque construction of epicycles.
All very true, but I would just note that the heliocentric model did not "win" because of a Bayesian comparison, and also not simply because it was simpler, but because it gave a more satisfactory (and in the end also more accurate) explanation of celestial mechanics, including the strange retrograde movements of the wandering stars. The Ptolemaic model had held out for a very long time because it was very accurate -- it also allowed indefinitely many adjustments to keep it accurate! --, but it basically provided no explanation for the movements of planets, but merely a kinematic, mathematical model.