One way is to look at sys.maxsize as documented here:
$ python-32 -c 'import sys;print("%x" % sys.maxsize, sys.maxsize > 2**32)' ('7fffffff', False) $ python-64 -c 'import sys;print("%x" % sys.maxsize, sys.maxsize > 2**32)' ('7fffffffffffffff', True)
On Windows, run the same commands formatted as follows:
python -c "import sys;print(\"%x\" % sys.maxsize, sys.maxsize > 2**32)"
sys.maxsize was introduced in Python 2.6. If you need a test for older systems, this slightly more complicated test should work on all Python 2 and 3 releases:
$ python-32 -c 'import struct;print( 8 * struct.calcsize("P"))' 32 $ python-64 -c 'import struct;print( 8 * struct.calcsize("P"))' 64
BTW, you might be tempted to use platform.architecture() for this. Unfortunately, its results are not always reliable, particularly in the case of OS X universal binaries.
$ arch -x86_64 /usr/bin/python2.6 -c 'import sys,platform; print platform.architecture()[0], sys.maxsize > 2**32' 64bit True $ arch -i386 /usr/bin/python2.6 -c 'import sys,platform; print platform.architecture()[0], sys.maxsize > 2**32' 64bit False