Another approach with sed is to anchor the replacement to the digits at the end of the line with:
sed '/^jack,/s/[0-9][0-9]*$/12/' file
This uses the form sed '/find/s/match/replace' where find locates at the beginning of the line '^' the word "jack," eliminating all ambiguity with, e.g. jackson,33. Then the normal substitution form of 's/match/replace/' where match locates at least one digit at the end of the line (anchored by '$') and replaces it with the 12 (or whatever you choose).
Example Use/Output
With your example file in file, you would have:
$ sed '/^jack,/s/[0-9][0-9]*$/12/' file student,marks jack,12 peter,20 rick,10
(note: the POSIX character class of [[:digit:]] is equivalent to [0-9] which is another alternative)
The equivalent expression using the POSIX character class would be:
sed '/^jack,/s/[[:digit:]][[:digit:]]*$/12/' file
You can also use Extended Regular Expression which provides the '+' repetition operator to indicate one-or-more compared to the basic repetition designator of '*' to indicate zero-or-more. The equivalent ERE would be sed -E '/^jack,/s/[0-9]+$/12/' file
You can add the -i option to edit in-place and/or using it as -i.bak to create a backup of the original with the .bak extension before modifying the original.
awk ... numbers.txt > output && mv output numbers.txtor similar.sed -i 's/jack,.*/jack,12/g' numbers.txtwhere 12 is the new mark