Since Wooldridge has written more than one books, the reference points to "Econometric Analysis of Cross Section and Panel Data". I have what it appears to be the 1st edition (2002), and in here it says that the variable $z_1$ is a candidate instrument for regressor $x_k$ if the following holds: $$[(5.3),\; p.83]\;\; Cov(z_1,u) = 0 \;\;(\Rightarrow E(z_1u)=0)$$
$$[(5.4)-(5.5), p.83-84] \;\;\text {in}\;\; x_k = \delta_0+\delta_1x_1+...+\delta_{k-1}+\theta_1z_1+r_k,\;\; \theta_1\neq0$$
The first condition (zero covariance) is indeed the standard one made, and is weaker than mean-independence, that is written in the question. What this condition does is to make the IV estimator consistent.
The second condition says that $z_1$ is correlated with $x_k$ even in the presence of the other regressors. Intuitively, if the other regressors do not leave room for $z_1$ to "explain" (i.e. "represent the variability of") $x_k$, then inserting $z_1$ in place of $x_k$ in the $y$-regression, all variability of the now absent $x_k$ will be "taken on" by the other $x$'s, and $z_1$ will be left powerless to help us recover the value of $\beta_1$. Formally, $\beta_1$ will no longer be identifiable, i.e. we would not have a unique solution. Wooldridge states this further down pp 85-86.
When only one variable is present, we indeed only need to assume that $z_1$ is correlated with $x_1$, since no other regressors exist. In their presence, the conditions for a valid instrument have to be stronger.