Questions tagged [biostatistics]
The science of statistics applied to the analysis of biological or medical data.
1,448 questions
0 votes
0 answers
20 views
Defining final interval for Andersen-Gill Model
I am analyzing a dataset of recurring events for a sample of patients. Each interval is categorized as ending in a hospitalization or not a hospitalization. I am looking to define the final interval ...
- 1
0 votes
0 answers
11 views
How to determine unit size for Taylor's Power Law?
How to determine unit size for Taylor's Power Law to assess overall degree of heterogeneity in spatial patterns? I tested eight different varieties (A, B, C, D, E, F, G, H) in the field against a ...
- 435
2 votes
1 answer
101 views
Singularity error in a fully nested linear mixed effects model
My experiment consists of evaluating certain behavioral parameters of tracked larvae using a nested linear mixed effects model. One experimental "Phase" consists of ("LightCondition&...
- 21
2 votes
1 answer
58 views
Should differential expression analysis be incorporated in cross validation for training machine learning models?
I'm conducting some experiments using TCGA-LUAD clinical and RNA-Seq count data. I'm building machine learning models for survival prediction (Random Survival Forests, Survival Support Vector Machines,...
- 21
5 votes
1 answer
81 views
Including finite population to power analysis
I’m estimating how many patients need to be surveyed annually to detect a 10% change in over a 10-year monitoring period. My response variable is binary (1 = yes, 0 = no). I’ve set the significance ...
- 51
4 votes
1 answer
81 views
Is UMAP advisable for clustering analysis in microbiome data?
I have a soil microbiome study in which we obtained two profiles (200 samples x 100,000 features and the same 200 samples x 5000 features, respectively), as well as a number of soil parameters ...
- 149
0 votes
0 answers
77 views
Durbin-Watson test for weighted linear regression
My question concerns the use of the Durbin-Watson test for a weighted linear model in the context of calibration curves (a simple model y = ax + b in my case). I saw that there is a similar question ...
- 31
0 votes
0 answers
42 views
Unaccounted for residual dependence in hierarchical GAM
I'm in need of some advice on how to account for residual dependence in a fitted GAM that doesn't appear to be driven by temporal structure in the data. In summary, I am working with a long-term ...
1 vote
0 answers
57 views
Modeling delivery time of radiotherapy as exposure - aggregate or not? and which hypothesis test?
I am analyzing the effect of radiotherapy delivery time (time of day) on long-term treatment-related cardiotoxicity in breast cancer patients. The biological hypothesis is that DNA repair mechanisms ...
2 votes
0 answers
47 views
GLMM BACI and covariates
I’m hoping to do a GLMM on this BACI study I have been doing, and wanted to see if it is normal or feasible to add in some habitat covariates that might help explain response variable, as someone ...
1 vote
0 answers
55 views
How to interpret output from a joint model in R?
I’m very new to joint models, and I could really use some help understanding what I’m doing and how to interpret the results. I’m working with a longitudinal biomarker measured at 4 different time ...
- 11
9 votes
4 answers
761 views
Is a normality test always performed on errors and not on raw data?
This question is mainly because I see many tutorials, whether on YouTube videos or on websites, forums, and the like, where when using software like SPSS, they always apply normality tests directly to ...
0 votes
0 answers
85 views
Is controlling for the mediator the same as controlling for the confounder?
I understand that it is a convention for statisticians to control for mediators to observe the direct effects of an exposure. However, is it appropriate to do so? Let's look at an example below: In ...
- 309
0 votes
0 answers
40 views
Which hypothesis test should I use when response variables are correlated （MRI， brain functions）?
I'm facing a multiple testing problem. I have two groups of people (health and disease), and I'm interested in the differences in their brain functions. There are many measures of brain function, and ...
0 votes
0 answers
89 views
DESeq2 used with zinbwave weights - Differences on contrasts calculations [closed]
I have been using DESeq2 together with weights obtained from the zinbwave package for shotgun data analysis (as proposed here in the case of single-cell applications: https://genomebiology....
- 1