import subprocess import os print os.path.exists("C:/Users/Dhruv/Desktop/Motivation/RiseShine.mp4") p = subprocess.Popen(["C:/Program Files (x86)/VideoLAN/VLC/vlc.exe","C:/Users/Dhruv/Desktop/Motivation/RiseShine.mp4"]) The code above is to open a video file in VLC player using python. The VLC player opens up, but does not run the video. I have checked the video location, it is correct. Can somebody tell me how to make this work?