I need to implement the following function en1 = (b4⊕b3⊕b2⊕b1⊕b0)' using the minimum number of NAND gates.

simulate this circuit – Schematic created using CircuitLab
How can I achieve the optimal implementation using the fewest possible NAND gates? Should I replace the XOR gates in the schematic above with their equivalent using NAND gates, or should I express the function in Sum of Products (SOP) form, then apply De Morgan's Theorem by negating twice? In the second option, I end up with 16 5-input NAND gates, plus an additional 16-input NAND gate since I got 16 minterms and the function has 5 variables.

hard. You might also examine this paper . That said, have a look at this minimization for XOR using NAND. It's just slightly non-obvious. But it provides a segue into recognizing the general difficulties for larger problems. \$\endgroup\$