Rails is a web application framework written in Ruby that makes programming web applications easier. The key principles of Rails are DRY (Don't Repeat Yourself), convention over configuration, and using RESTful architecture. Rails uses the MVC pattern with models representing data, views representing the user interface, and controllers handling requests and passing data between models and views. Creating a Rails application involves generating the app, setting up the database schema through migrations, and using validations and callbacks to control object state changes.